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Sinarest Sinus and Zykadia

Determining the interaction of Sinarest Sinus and Zykadia and the possibility of their joint administration.

Check result:

Sinarest Sinus <> Zykadia

Relevance: 25.10.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ceritinib may increase the blood levels and effects of acetaminophen. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with ceritinib may increase the plasma concentration and the risk of adverse effects of drugs that are substrates of CYP450 2A6 and/or 2E1. The proposed mechanism, based on in vitro data, is decreased clearance due to ceritinib-mediated inhibition of CYP450 2A6 and 2E1.

MANAGEMENT: Caution is advised if ceritinib is used concomitantly with drugs that are substrates of CYP450 2A6 and/or 2E1, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever ceritinib is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.

References

Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Cerner Multum, Inc. "Australian Product Information." O 0
EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):

Sinarest Sinus

Generic Name: acetaminophen / pseudoephedrine

Brand name: Alka-Seltzer Cold and Sinus, Allerest No Drowsiness, Bayer Select Decongestant, Benadryl Allergy Sinus Headache, Dristan Cold Non-Drowsy, Ornex, Ornex Maximum Strength, Sinarest Sinus, Sine-Off Maximum Strength, Tavist Sinus, Triaminic Softchews Allergy Sinus, Bayer Select Sinus Pain Formula, Sudafed Sinus, Contac Sinus, Sinutab Regular Strength, Tylenol Sinus Maximum Strength, Excedrin Sinus, Genapap Sinus, Mapap Sinus, Suphedrin Plus, Phenapap, Pseudoephedrine Sinus, Sinutab Maximum Strength, Sinus Maximum Strength, Tylenol Cold Infants, Suphedrin Sinus, Theraflu Sinus, Sudafed Cold and Sinus, Sudogest Sinus Maximum Strength, Children's Tylenol Sinus, Tylenol Sinus Childrens, Sudafed Sinus Headache, Sinutab Maximum Strength Non Drowsy, Tylenol Sinus Gelcap, Nexafed Sinus Pressure + Pain

Synonyms: n.a.

What is Sinarest Sinus?

Zykadia

Generic Name: ceritinib

Brand name: Zykadia

Synonyms: n.a.

What is Zykadia?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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