Sinemet 100/10 and Trihexyphenidyl
Determining the interaction of Sinemet 100/10 and Trihexyphenidyl and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using levodopa together with trihexyphenidyl may decrease the effects of levodopa. Contact your doctor if you experience an increase in involuntary body movements or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSE: Concomitant administration of trihexyphenidyl and levodopa may increase involuntary movements. The anticholinergic agent delays gastric emptying, thereby increasing gastrointestinal deactivation of levodopa and decreasing its absorption. In one study, levodopa peak serum concentrations were reduced by 16% to 20%.
MANAGEMENT: The dosage of both drugs may require reduction. The manufacturer recommends total daily trihexyphenidyl doses of 3 to 6 mg when given concurrently with levodopa. Patients should be monitored for symptom control and side effects.
- Rivera-Calimlim L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "Absorption and metabolism of L-dopa by the human stomach." Eur J Clin Invest 1 (1971): 313-20
- Algeri S, Cerletti C, Curcio M, et al. "Effect of anticholinergic drugs on gastro-intestinal absorption of L-dopa in rats and man." Eur J Pharmacol 35 (1976): 293-9
- "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories, Wayne, NJ.
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: Carbidopa and levodopa, Carbidopa and Levodopa
Generic Name: trihexyphenidyl
Brand name: Artane, Trihexane
Synonyms: n.a.
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sinemet 100/10-Trihexyphenidyl Elixir
- Sinemet 100/10-Trihexyphenidyl Hydrochloride
- Sinemet 100/10-Trihexyphenidyl Oral Solution
- Sinemet 100/10-Trihexyphenidyl Tablets
- Sinemet 100/10-Trikafta
- Sinemet 100/10-Triklo
- Trihexyphenidyl-Sinemet 100/25
- Trihexyphenidyl-Sinemet 25-100
- Trihexyphenidyl-Sinemet 25-250
- Trihexyphenidyl-Sinemet 250/25
- Trihexyphenidyl-Sinemet CR
- Trihexyphenidyl-Sinemet CR 100/25