Sinemet CR and Sodium Bicarbonate Infant Injection
Determining the interaction of Sinemet CR and Sodium Bicarbonate Infant Injection and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Antacids and some oral aluminum, calcium, or magnesium containing preparations may increase the absorption of levodopa. The mechanisms may be related to increased gastric pH and/or decreased gastric emptying time, resulting in less gastric degradation of levodopa and more levodopa absorption from the small intestine. This effect may be beneficial in some patients, but also difficult to predict and monitor. For most patients, this interaction is not clinically significant and no specific intervention would be required. Dosing intervals could be spaced by at least 2 hours if it is preferred to avoid this interaction.
- Rivera-Calimlim L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "Absorption and metabolism of L-dopa by the human stomach." Eur J Clin Invest 1 (1971): 313-20
- "Product Information. Sinemet (carbidopa-levodopa)." DuPont Pharmaceuticals, Wilmington, DE.
- Fermaglich J, O'Dougherty DS "Effect of gastric motility on levodopa." Dis Nerv Syst 33 (1972): 624-5
- Rivera-Calimlin L, Dujovne CA, Morgan JP, Lasagna L, Bianchine JR "L-dopa treatment failure: explanation and correction." Br Med J 4 (1970): 93-4
Generic Name: carbidopa / levodopa
Brand name: Parcopa, Rytary, Sinemet, Sinemet CR, Duopa
Synonyms: n.a.
Generic Name: sodium bicarbonate
Brand name: Neut
Synonyms: Sodium bicarbonate, Sodium Bicarbonate
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sinemet CR-Sodium Bicarbonate Injection
- Sinemet CR-Sodium bicarbonate Oral, Intravenous, Subcutaneous
- Sinemet CR-Sodium Bicarbonate Tablets
- Sinemet CR-Sodium Bicarbonate, Citric Acid, and Simethicone Effervescent Granule Pkt
- Sinemet CR-Sodium biphosphate and sodium phosphate
- Sinemet CR-Sodium biphosphate and sodium phosphate rectal
- Sodium Bicarbonate Infant Injection-Sinemet CR 100/25
- Sodium Bicarbonate Infant Injection-Sinemet CR 200/50
- Sodium Bicarbonate Infant Injection-Sinequan
- Sodium Bicarbonate Infant Injection-Sinequan (Doxepin Capsules)
- Sodium Bicarbonate Infant Injection-Sinequan (Doxepin Oral Concentrate)
- Sodium Bicarbonate Infant Injection-Sinex Long-Acting