Sirturo and Tylenol Warming Cough & Sore Throat Nightime

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Bedaquiline may cause liver problems, and using it with other medications that can also affect the liver such as acetaminophen may increase that risk. You should avoid or limit the use of alcohol while being treated with these medications. Call your doctor immediately if you have fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes, as these may be signs and symptoms of liver damage. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration of bedaquiline with other agents known to induce hepatotoxicity may potentiate the risk of liver injury. In clinical trials, hepatic adverse drug reactions developed in more bedaquiline-treated patients than in those who received other drugs used to treat tuberculosis. In patients receiving bedaquiline or placebo in combination with other drugs used to treat multidrug-resistant tuberculosis, reversible aminotransferase elevations of at least 3 times the upper limit of normal (ULN) developed more frequently in the bedaquiline treatment group [10.8%] than in the placebo group [5.7%].

MANAGEMENT: The use of bedaquiline with other potentially hepatotoxic agents should be avoided whenever possible (e.g., acetaminophen; alcohol; androgens and anabolic steroids; other antituberculous agents; azole antifungal agents; ACE inhibitors; disulfiram; endothelin receptor antagonists; ketolide and macrolide antibiotics; interferons; kinase inhibitors; minocycline; nonsteroidal anti-inflammatory agents; nucleoside reverse transcriptase inhibitors; proteasome inhibitors; retinoids; sulfonamides; tamoxifen; thiazolidinediones; tolvaptan; vincristine; zileuton; anticonvulsants such as carbamazepine, hydantoins, felbamate, and valproic acid; lipid-lowering medications such as fenofibrate, lomitapide, mipomersen, niacin, and statins; herbals and nutritional supplements such as black cohosh, chaparral, comfrey, DHEA, kava, pennyroyal oil, and red yeast rice), especially in patients with diminished hepatic reserve. Patients treated with bedaquiline should have serum ALT, AST, alkaline phosphatase, and bilirubin monitored at baseline and monthly during treatment, or as often as needed. An increase of serum aminotransferases to greater than 3 times ULN should be followed by repeat testing within 48 hours. Patients should be advised to seek medical attention if they experience potential signs and symptoms of hepatotoxicity such as fever, rash, itching, anorexia, nausea, vomiting, fatigue, malaise, right upper quadrant pain, dark urine, pale stools, and jaundice. Discontinue bedaquiline if aminotransferase elevations are accompanied by total bilirubin elevation greater than 2 times ULN, aminotransferase elevations are greater than 8 times ULN, or aminotransferase elevations persist beyond 2 weeks.

Sirturo

Generic Name: bedaquiline

Brand name: Sirturo

Synonyms: n.a.

What is Sirturo?

Tylenol Warming Cough & Sore Throat Nightime

Generic Name: acetaminophen / dextromethorphan / doxylamine

Brand name: All-Nite, Contac Cold+Flu Cooling Night, Coricidin HBP Nighttime Multi-Symptom Cold, Night Time Cold/Flu, Nyquil Cold & Flu, Robitussin Peak Cold Nighttime Cold + Flu, Tylenol Cold & Cough Nighttime Cool Burst, Tylenol Warming Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Nightime, Tylenol Cough & Sore Throat Night Time, NyQuil Cold/Flu Relief Cherry, NyQuil Cold/Flu Relief, Nite Time Cold & Flu, Cough & Sore Throat Nighttime, Delsym Cough-Cold Nighttime, Sunmark Nite Time Cold and Flu, Delsym Nighttime Cough & Cold, Multi-Symptom Nighttime Cold & Flu Relief, Nyquil Cold & Flu Nighttime, NyQuil Nature Fusion Cold & Flu Nighttime, Clear Cough PM Multi-Symptom, Tylenol Cough/Sore Throat

Synonyms: Acetaminophen, dextromethorphan, and doxylamine

What is Tylenol Warming Cough & Sore Throat Nightime?