Sitagliptin and metformin and Sylvant

• Generic Name: metformin / sitagliptin
• Dosage Forms: n.a.
• Other Brand Names: Janumet, Janumet XR

Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Metformin reduces the absorption of sugar from the stomach, reduces the release of stored sugar from the liver, and helps your body use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing sugar (glucose) when there is too much sugar in the blood. Sitagliptin and metformin does not help patients who have insulin-dependent or type 1 diabetes.

Sitagliptin and metformin is available only with your doctor's prescription.

• Generic Name: siltuximab
• Dosage Forms: injection, powder, lyophilized, for solution
• Other Brand Names: Sylvant

Sylvant (siltuximab) inhibits a certain protein in the body called interleukin-6 (IL-6). High levels of IL-6 can cause an overgrowth of cells in the lymph system (part of your immune system).

Sylvant is used to treat Multicentric Castleman's Disease (MCD). MCD is a rare condition in which the body produces too much of a certain type of white blood cell. MCD can increase your risk of certain cancers by changing the way your immune system works.

Sylvant is not for use in people who have human immunodeficiency virus (HIV) or human herpesvirus-8.