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Sitagliptin and simvastatin and Zithromax Tri-Pak

Determining the interaction of Sitagliptin and simvastatin and Zithromax Tri-Pak and the possibility of their joint administration.

Check result:

Sitagliptin and simvastatin <> Zithromax Tri-Pak

Relevance: 03.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using azithromycin together with simvastatin may increase your risk of a dangerous side effect on your muscles. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely take both medications. You should also watch for muscle symptoms and call the doctor if you have muscle pain, tenderness, or weakness, especially if you also have dark colored urine. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Azithromycin has been implicated in a single case of rhabdomyolysis during lovastatin treatment. The mechanism of interaction is unknown. Macrolide antibiotics that inhibit CYP450 3A4 may significantly increase the plasma concentrations of HMG-CoA reductase inhibitors; however, azithromycin is generally believed to have little, if any, effect on this isoenzyme. In 12 healthy patients treated with atorvastatin (10 mg once a day for 8 days), the pharmacokinetics of atorvastatin were not significantly changed following 3 days of azithromycin (500 mg once a day from days 6 through 8).

MANAGEMENT: Until further data are available, caution is advised if azithromycin is prescribed to patients treated with HMG-CoA reductase inhibitors or red yeast rice (which contains lovastatin). Patients should be advised to promptly report any unexplained muscle pain, tenderness, or weakness, particularly if accompanied by malaise or fever. The HMG-CoA reductase inhibitor should be discontinued if creatine kinase is markedly elevated or if myopathy is suspected or diagnosed.

References

"Product Information. Mevacor (lovastatin)." Merck & Co, Inc, West Point, PA.
"Product Information. Zocor (simvastatin)." Merck & Co, Inc, West Point, PA.
Amsden GW, Kuye O, Wei GC "A study of the interaction potential of azithromycin and clarithromycin with atorvastatin in healthy volunteers." J Clin Pharmacol 42 (2002): 444-9
"Product Information. Baycol (cerivastatin)." Bayer, West Haven, CT.
"Product Information. Lipitor (atorvastatin)." Parke-Davis, Morris Plains, NJ.
Westphal JF "Macrolide - induced clinically relevant drug interactions with cytochrome P-450 (CYP) 3A4: an update focused on clarithromycin, azithromycin, and dirithromycin." Br J Clin Pharmacol 50 (2000): 285-95
Grunden JW, Fisher KA "Lovastatin-induced rhabdomyolysis possibly associated with clarithromycin and azithromycin." Ann Pharmacother 31 (1997): 859-63

Sitagliptin and simvastatin

Generic Name: simvastatin / sitagliptin

Brand name: Juvisync

Synonyms: Sitagliptin and simvastatin (Oral)

What is Sitagliptin and simvastatin?

Zithromax Tri-Pak

Generic Name: azithromycin

Brand name: Zithromax, Zmax, AzaSite, Azithromycin 3 Day Dose Pack, Azithromycin 5 Day Dose Pack, Zithromax Tri-Pak, Zithromax Z-Pak, Zithromax IV

Synonyms: Zithromax

What is Zithromax Tri-Pak?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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