Sodium Chloride Injection 0.45% and Tolvaptan (Samsca)
Determining the interaction of Sodium Chloride Injection 0.45% and Tolvaptan (Samsca) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using tolvaptan together with sodium chloride. Combining these medications may cause sodium levels to increase too rapidly. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: The use of tolvaptan with other treatments for hyponatremia or medications that increase serum sodium concentration may increase the risk of rapid correction of sodium levels due to additive effects. Other products with high sodium content such as oral sodium, effervescent analgesic preparations,or treatments for dyspepsia may also increase serum sodium concentration.
MANAGEMENT: The concomitant use of tolvaptan with hypertonic saline is not recommended. Caution and monitoring are recommended for patients who have received other medications that increase serum sodium levels.
- "Product Information. Samsca (tolvaptan)." Otsuka American Pharmaceuticals Inc, Rockville, MD.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Generic Name: sodium chloride
Brand name: BD PosiFlush SF, Normal Saline flush, Swabflush, Syrex, Thermoject, Tip-Lok Diluent, Hyper-Sal, Nebusal, Sodium chloride, Inhalation, HyperSal, Nebusal, PulmoSal, Altachlore, Muro 128, Sochlor, Adsorbonac, AK-NaCl
Synonyms: Sodium chloride (flush), Sodium Chloride
Generic Name: tolvaptan
Brand name: Samsca, Jynarque
Synonyms: Tolvaptan
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
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