Sodium phenylbutyrate and Uceris (Budesonide Extended-Release Tablets)
Determining the interaction of Sodium phenylbutyrate and Uceris (Budesonide Extended-Release Tablets) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Talk to your doctor before using budesonide together with sodium phenylbutyrate. Budesonide may increase ammonia levels in the blood and reduce the effectiveness of sodium phenylbutyrate in the treatment of urea cycle disorders. You may need a dosage adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Drugs that can increase plasma ammonia levels such as corticosteroids, haloperidol, or the anticonvulsants carbamazepine, topiramate, and phenobarbital may interfere with the therapeutic effects of phenylbutyrate therapy in the management of urea cycle disorders. Corticosteroids can cause the breakdown of body protein, which may lead to increased ammonia levels. The use of haloperidol has been associated with hyperammonemia in a young child with citrullinemia, an inherited disorder of ammonia excretion. The mechanism for haloperidol, carbamazepine, topiramate, and phenobarbital has not been established.
MANAGEMENT: Plasma ammonia levels should be closely monitored when corticosteroids, haloperidol, carbamazepine, topiramate, or phenobarbital are used in patients with urea cycle disorders receiving phenylbutyrate therapy.
- "Product Information. Ravicti (glycerol phenylbutyrate)." Hyperion Therapeutics Inc, South San Francisco, CA.
- Cerner Multum, Inc. "Australian Product Information." O 0
- "Product Information. Buphenyl (sodium phenylbutyrate)." Horizon Pharma USA Inc, Northbrook, IL.
Generic Name: sodium phenylbutyrate
Brand name: Buphenyl
Synonyms: Sodium Phenylbutyrate Powder
Generic Name: budesonide
Brand name: Entocort EC, Uceris, Pulmicort Flexhaler, Pulmicort Respules
Synonyms: Uceris, Uceris Foam
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sodium phenylbutyrate-Uceris (Budesonide Rectal Foam)
- Sodium phenylbutyrate-Uceris Foam
- Sodium phenylbutyrate-Uceris Rectal
- Sodium phenylbutyrate-Uceris Tablets
- Sodium phenylbutyrate-Udenyca
- Sodium phenylbutyrate-Ulipristal
- Uceris (Budesonide Extended-Release Tablets)-Sodium Phenylbutyrate Powder
- Uceris (Budesonide Extended-Release Tablets)-Sodium Phenylbutyrate Tablets
- Uceris (Budesonide Extended-Release Tablets)-Sodium phosphate dibasic and sodium phosphate monobasic
- Uceris (Budesonide Extended-Release Tablets)-Sodium phosphate dibasic and sodium phosphate monobasic Rectal
- Uceris (Budesonide Extended-Release Tablets)-Sodium phosphate p 32 Intravenous
- Uceris (Budesonide Extended-Release Tablets)-Sodium Phosphates