Sotalol Injection and Tramadol Tablets
Determining the interaction of Sotalol Injection and Tramadol Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using sotalol together with traMADol can increase the risk of an irregular heart rhythm that may be serious and potentially life-threatening, although it is a relatively rare side effect. You may be more susceptible if you have a heart condition called congenital long QT syndrome, other cardiac diseases, conduction abnormalities, or electrolyte disturbances (for example, magnesium or potassium loss due to severe or prolonged diarrhea or vomiting). Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations during treatment with these medications, whether together or alone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:GENERALLY AVOID: Class IA (e.g., disopyramide, quinidine, procainamide) and class III (e.g., amiodarone, dofetilide, sotalol) antiarrhythmic agents can cause dose-related prolongation of the QT interval. Theoretically, coadministration with other agents that can prolong the QT interval may result in additive effects and increased risk of ventricular arrhythmias including torsade de pointes and sudden death. In general, the risk of an individual agent or a combination of agents causing ventricular arrhythmia in association with QT prolongation is largely unpredictable but may be increased by certain underlying risk factors such as congenital long QT syndrome, cardiac disease, and electrolyte disturbances (e.g., hypokalemia, hypomagnesemia). In addition, the extent of drug-induced QT prolongation is dependent on the particular drug(s) involved and dosage(s) of the drug(s).
MANAGEMENT: Coadministration of class IA or class III antiarrhythmic agents with other drugs that can prolong the QT interval should preferably be avoided unless benefits are anticipated to outweigh the risks. Caution and clinical monitoring are recommended if concomitant use is required. Patients should be advised to seek prompt medical attention if they experience symptoms that could indicate the occurrence of torsade de pointes such as dizziness, lightheadedness, fainting, palpitation, irregular heart rhythm, shortness of breath, or syncope.
- Canadian Pharmacists Association "e-CPS. Available from: URL: http://www.pharmacists.ca/function/Subscriptions/ecps.cfm?link=eCPS_quikLink."
- Yamreudeewong W, DeBisschop M, Martin L, Lower D "Potentially Significant Drug Interactions of Class III Antiarrhythmic Drugs." Drug Saf 26 (2003): 421-38
- Maxa JL, Hebeler RF, Adeeko MA "Torsades de pointes following concurrent amiodarone and levofloxacin therapy." Proc (Bayl Univ Med Cent) 19 (2006): 345-6
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- "Product Information. Norpace (disopyramide)." Searle, Skokie, IL.
- "Product Information. Vascor (bepridil)." McNeil Pharmaceutical, Raritan, NJ.
- "Product Information. Betapace (sotalol)." Berlex, Richmond, CA.
- "Product Information. Quiniglute (quinidine)." Berlex, Richmond, CA.
- Trujillo TC, Nolan PE "Antiarrhythmic agents - Drug interactions of clinical significance." Drug Safety 23 (2000): 509-32
- "Product Information. Procan SR (procainamide)." Parke-Davis, Morris Plains, NJ.
- "Product Information. Cordarone (amiodarone)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- EMA. European Medicines Agency. European Union "EMA - List of medicines under additional monitoring. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/regulation/document_listing/document_listing_000366.jsp&mid=WC0b01ac058067c852" ([2013 - ]):
- Cerner Multum, Inc. "Australian Product Information." O 0
Generic Name: sotalol
Brand name: Betapace, Betapace AF, Sorine, Sotalol Hydrochloride AF, Sotylize
Synonyms: Sotalol
Generic Name: tramadol
Brand name: ConZip, Ultram, Ultram ER, Rybix ODT, Ryzolt
Synonyms: Tramadol, TraMADol
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sotalol Injection-Tramapap
- Sotalol Injection-Trametinib
- Sotalol Injection-Trametinib Dimethyl Sulfoxide
- Sotalol Injection-Trancot
- Sotalol Injection-Trandate
- Sotalol Injection-Trandate (Labetalol Injection)
- Tramadol Tablets-Sotalol Intravenous
- Tramadol Tablets-Sotalol Oral Solution
- Tramadol Tablets-Sotalol Tablets
- Tramadol Tablets-Sotret
- Tramadol Tablets-Sotylize
- Tramadol Tablets-Sovaldi