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Sporanox and Videx EC

Determining the interaction of Sporanox and Videx EC and the possibility of their joint administration.

Check result:

Sporanox <> Videx EC

Relevance: 18.12.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using didanosine together with itraconazole may decrease the effects of itraconazole. Separation of doses by two hours is recommended. It may be preferable to administer itraconazole first. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSING INTERVAL: The buffer system of didanosine may reduce absorption of itraconazole by increasing gastric pH. Treatment failure may result.

MANAGEMENT: Separation of doses by two hours is recommended. It may be preferable to administer itraconazole first. Fluconazole does not appear to interact with didanosine.

References

May DB, Drew RH, Yedinak KC, Bartlett JA "Effect of simultaneous didanosine administration on itraconazole absorption in healthy volunteers." Pharmacotherapy 14 (1994): 509-13
Moreno F, Hardin TC, Rimaldi MG, Graybill JR "Itraconazole-didanosine excipient interaction." JAMA 269 (1993): 1508

Sporanox

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Sporanox?

Videx EC

Generic Name: didanosine

Brand name: Videx, Videx EC

Synonyms: n.a.

What is Videx EC?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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