Sporanox (Itraconazole Oral Solution) and Sustiva

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Ask your doctor before using itraconazole together with efavirenz. Using these medications together may decrease the effects of efavirenz. Contact your doctor if your condition or infection worsens. If your doctor prescribes these medications together, you may need a dose adjustment or special tests to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with efavirenz can reduce the plasma concentrations and therapeutic efficacy of itraconazole. The mechanism is efavirenz induction of CYP450 3A4, the isoenzyme responsible for the metabolic clearance of itraconazole. When efavirenz (600 mg orally daily for 14 days) was administered with itraconazole (200 mg orally every 12 hours for 28 days) in 18 study subjects, the systemic exposure (AUC) of itraconazole decreased by 39%, and the maximum and minimum plasma concentrations decreased by 37% and 44%, respectively. Plasma concentrations of hydroxyitraconazole were similarly reduced. In contrast, itraconazole had no significant effect on the pharmacokinetics of efavirenz.

MANAGEMENT: No dosage recommendations for itraconazole are available when used in combination with efavirenz. The manufacturer of efavirenz recommends use of other antifungal agents.

Sporanox (Itraconazole Oral Solution)

Generic Name: itraconazole

Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura

Synonyms: Sporanox

What is Sporanox (Itraconazole Oral Solution)?

Sustiva

Generic Name: efavirenz

Brand name: Sustiva

Synonyms: n.a.

What is Sustiva?