Sporanox PulsePak and Vandetanib
Determining the interaction of Sporanox PulsePak and Vandetanib and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with itraconazole has been shown to slightly increase the plasma concentrations of vandetanib, possibly by inhibiting the CYP450 3A4-mediated metabolism of vandetanib. In 16 healthy male subjects, coadministration of itraconazole (200 mg/day on days 1 to 24) and vandetanib (single 300 mg oral dose on day 4) resulted in a small but statistically significant 9% increase in vandetanib exposure (AUC) and an approximately 13% increase in half-life (from 209.2 hours to 235.5 hours) compared to vandetanib administered alone. These changes are not considered clinically relevant.
- Martin P, Oliver S, Robertson J, Kennedy SJ, Read J, Duvauchelle T "Pharmacokinetic drug interactions with vandetanib during cadministration with rifampicin or itraconazole." Drugs R D 11 (2011): 37-51
- "Product Information. Vandetanib (vandetanib)." Astra-Zeneca Pharmaceuticals, Wilmington, DE.
Generic Name: itraconazole
Brand name: Sporanox, Onmel, Sporanox PulsePak, Tolsura
Synonyms: Sporanox
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sporanox PulsePak-Vanos
- Sporanox PulsePak-Vanoxide-HC
- Sporanox PulsePak-Vanquish
- Sporanox PulsePak-Vanspar
- Sporanox PulsePak-Vantas
- Sporanox PulsePak-Vantin
- Vandetanib-Sportsmed Topical
- Vandetanib-Spravato
- Vandetanib-Spravato (56 MG Dose)
- Vandetanib-Spravato (84 MG Dose)
- Vandetanib-Sprintec
- Vandetanib-Sprintec 28