Stalevo 125 and Trihexyphenidyl Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using levodopa together with trihexyphenidyl may decrease the effects of levodopa. Contact your doctor if you experience an increase in involuntary body movements or if your condition changes. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Concomitant administration of trihexyphenidyl and levodopa may increase involuntary movements. The anticholinergic agent delays gastric emptying, thereby increasing gastrointestinal deactivation of levodopa and decreasing its absorption. In one study, levodopa peak serum concentrations were reduced by 16% to 20%.

MANAGEMENT: The dosage of both drugs may require reduction. The manufacturer recommends total daily trihexyphenidyl doses of 3 to 6 mg when given concurrently with levodopa. Patients should be monitored for symptom control and side effects.

Stalevo 125

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

What is Stalevo 125?

Trihexyphenidyl Tablets

Generic Name: trihexyphenidyl

Brand name: Artane, Trihexane

Synonyms: Trihexyphenidyl

What is Trihexyphenidyl Tablets?