Stalevo 150 and Warfarin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Coadministration with entacapone has been shown to slightly increase plasma concentrations of the less pharmacologically active R-enantiomer of warfarin. The mechanism of interaction is unknown. In a study of 12 healthy subjects, entacapone (200 mg orally four times a day for 1 week) increased the mean steady-state area under the plasma concentration-time curve (AUC) of R-warfarin by 18% compared to placebo. Other pharmacokinetic parameters of R-warfarin, as well as pharmacokinetics of S-warfarin, were not significantly affected. Entacapone increased the INR by an average of 13% relative to placebo, although safety and tolerability variables were not different between treatment phases. These changes are unlikely to be of clinical significance.

Stalevo 150

Generic Name: carbidopa / entacapone / levodopa

Brand name: Stalevo 100, Stalevo 125, Stalevo 150, Stalevo 200, Stalevo 50, Stalevo 75, Stalevo

Synonyms: n.a.

What is Stalevo 150?

Warfarin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Warfarin?