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Stribild and Xylocaine

Determining the interaction of Stribild and Xylocaine and the possibility of their joint administration.

Check result:

Stribild <> Xylocaine

Relevance: 14.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using lidocaine together with cobicistat. Combining these medications may increase the blood levels and effects of lidocaine. This can increase the risk of serious side effects such as irregular heart rhythm and other cardiovascular problems. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with cobicistat may increase the plasma concentrations of lidocaine. The proposed mechanism involves cobicistat inhibition of CYP450 3A4-mediated metabolism of lidocaine. The interaction has not been specifically studied, but could conceivably lead to serious and/or life-threatening reactions including cardiac arrhythmias and other toxicities if levels are significantly increased.

MANAGEMENT: Caution is advised if cobicistat must be used concomitantly with lidocaine. Pharmacologic response and plasma lidocaine levels should be monitored more closely whenever cobicistat is added to or withdrawn from therapy, and the lidocaine dosage adjusted as necessary.

References

"Product Information. Evotaz (atazanavir-cobicistat)." Bristol-Myers Squibb, Princeton, NJ.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Stribild

Generic Name: cobicistat / elvitegravir / emtricitabine / tenofovir

Brand name: Genvoya, Stribild

Synonyms: n.a.

What is Stribild?

Xylocaine

Generic Name: lidocaine

Brand name: UAD Caine, Xylocaine HCl, Xylocaine-MPF, Lidoject 1, Xylocaine Dental Cartridges, Lidoject 2, Xylocaine Duo-Trach Kit, Xylocaine HCl For Spinal, L-Caine, Dilocaine, Nervocaine, Truxacaine, Anestacaine

Synonyms: Lidocaine injection, Lidocaine (Systemic)

What is Xylocaine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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