Sucroferric oxyhydroxide and Vibramycin Hyclate
Determining the interaction of Sucroferric oxyhydroxide and Vibramycin Hyclate and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Sucroferric oxyhydroxide and doxycycline should not be taken orally at the same time. Products that contain iron such as sucroferric oxyhydroxide may interfere with the absorption of doxycycline and reduce its effectiveness. To prevent or minimize the interaction, you should take doxycycline at least one to four hours before sucroferric oxyhydroxide. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:ADJUST DOSING INTERVAL: Coadministration with sucroferric oxyhydroxide may reduce the oral bioavailability of tetracyclines. The proposed mechanism is chelation of tetracyclines to the ferric ion component of sucroferric oxyhydroxide, forming an insoluble complex that is poorly absorbed from the gastrointestinal tract. According to the product labeling for sucroferric oxyhydroxide, an in vitro interaction with doxycycline was observed when studied in aqueous solutions that mimic the physico-chemical conditions of the gastrointestinal tract. This is consistent with previous pharmacokinetic studies that have demonstrated a substantial interaction between tetracyclines and iron salts. In ten healthy volunteers, simultaneous oral administration of ferrous sulfate 200 mg and single doses of various tetracyclines (200 mg to 500 mg) resulted in reductions in the serum levels of methacycline and doxycycline by 80% to 90%, oxytetracycline by 50% to 60%, and tetracycline by 40% to 50%. In another study, 300 mg of ferrous sulfate reduced the absorption of tetracycline by 81% and that of minocycline by 77%.
MANAGEMENT: Doxycycline should be administered at least 1 hour before sucroferric oxyhydroxide. Omadacycline administration with sucroferric oxyhydroxide should be separated by 4 hours. No dosing recommendations are available for use with other tetracyclines, although patients should consider following the same precaution.
- Neuvonen PJ "Interactions with the absorption of tetracyclines." Drugs 11 (1976): 45-54
- "Product Information. Nuzyra (omadacycline)." Paratek Pharmaceuticals, Inc., Boston, MA.
- Greenberger NJ "Absorption of tetracyclines: interference by iron." Ann Intern Med 74 (1971): 792-3
- Campbell NR, Hasinoff BB "Iron supplements: a common cause of drug interactions." Br J Clin Pharmacol 31 (1991): 251-5
- "Product Information. Velphoro (sucroferric oxyhydroxide)." Fresenius Medical Care North America, Lexington, MA.
- Neuvonen PJ, Penttila O "Effect of oral ferrous sulphate on the half-life of doxycycline in man." Eur J Clin Pharmacol 7 (1974): 361-3
- Neuvonen PJ, Gothoni G, Hackman R, Bjorksten K "Interference of iron with the absorption of tetracyclines in man." Br Med J 4 (1970): 532-4
- Venho VM, Salonen RO, Mattila MJ "Modification of the pharmacokinetics of doxycycline in man by ferrous sulphate or charcoal." Eur J Clin Pharmacol 14 (1978): 277-80
- "Product Information. Seysara (sarecycline)." Allergan Inc, Irvine, CA.
- Gothoni G, Neuvonen PJ, Mattila M, Hackman R "Iron-tetracycline interaction: effect of time interval between the drugs." Acta Med Scand 191 (1972): 409-11
Generic Name: sucroferric oxyhydroxide
Brand name: Velphoro
Synonyms: Sucroferric Oxyhydroxide
Generic Name: doxycycline
Brand name: Acticlate, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Monodox, Morgidox, Oracea, Oraxyl, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, TargaDOX, Vibramycin, Doxy 100, TargaDOX
Synonyms: Doxycycline
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Sucroferric oxyhydroxide-Vicks 44 Cold, Flu and Cough
- Sucroferric oxyhydroxide-Vicks 44 Cough Relief
- Sucroferric oxyhydroxide-Vicks DayQuil Multi-Symptom
- Sucroferric oxyhydroxide-Vicks DayQuil Multi-Symptom Cold/Flu Relief
- Sucroferric oxyhydroxide-Vicks DayQuil Severe Cold/Flu
- Sucroferric oxyhydroxide-Vicks DayQuil Sinex
- Vibramycin Hyclate-Sudafed
- Vibramycin Hyclate-Sudafed 12 Hour
- Vibramycin Hyclate-Sudafed 12 Hour Pressure + Pain
- Vibramycin Hyclate-Sudafed 24 Hour
- Vibramycin Hyclate-Sudafed Childrens
- Vibramycin Hyclate-Sudafed OM Sinus Cold