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Sufentanil Injection and Xanax

Determining the interaction of Sufentanil Injection and Xanax and the possibility of their joint administration.

Check result:

Sufentanil Injection <> Xanax

Relevance: 27.08.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using SUFentanil together with other medications that cause central nervous system depression such as ALPRAZolam can lead to serious side effects including respiratory distress, coma, and even death. Decreased heart rate and blood pressure may also occur during anesthesia with these medications. You should be closely monitored by medical staff during your procedure. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Concomitant use of opioids with benzodiazepines may result in profound sedation, respiratory depression, coma, and death. The use of benzodiazepines with sufentanil during induction has been reported to decrease mean arterial pressure and systemic vascular resistance. The mechanism appears to be an indirect effect on the autonomic nervous system.

MANAGEMENT: The use of opioids in conjunction with benzodiazepines or other CNS depressants should generally be avoided unless alternative treatment options are inadequate. If coadministration is necessary, the dosage and duration of each drug should be limited to the minimum required to achieve desired clinical effect. Patients receiving sufentanil with benzodiazepines should be monitored closely for signs and symptoms of respiratory depression, altered hemodynamics, and hypotension.

References

Gilman AG, Rall TW, Nies AS, Taylor P, eds. "Goodman and Gilman's the Pharmacological Basis of Therapeutics. 8th ed." New York, NY: Pergamon Press Inc. (1990):
West JM, Estrada S, Heerdt M "Sudden hypotension associated with midazolam and sufentanil." Anesth Analg 66 (1987): 693-4
Thomson IR, MacAdams CL, Hudson RJ, Rosenbloom M "Drug interactions with sufentanil: hemodynamic effects of premedication and muscle relaxants." Anesthesiology 76 (1992): 922-9
"Product Information. Sufenta (sufentanil)." Janssen Pharmaceutica, Titusville, NJ.
US Food and Drug Administration "FDA warns about serious risks and death when combining opioid pain or cough medicines with benzodiazepines; requires its strongest warning. Available from: URL: http://www.fda.gov/downloads/Drugs/DrugSafety/UCM518672.pdf." ([2016, Aug 31]):

Sufentanil Injection

Generic Name: sufentanil

Brand name: Dsuvia

Synonyms: Sufentanil Sublingual Tablets, SUFentanil

What is Sufentanil Injection?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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