Sugammadex Sodium and Xermelo

• Generic Name: sugammadex
• Dosage Forms: n.a.
• Other Brand Names: Bridion

Used to reverse neuromuscular blockade induced by rocuronium or vecuronium in patients undergoing surgery.

Reduces time to recovery of neuromuscular function when administered at moderate (reappearance of the second twitch [T2] in a train-of-four [TOF] stimulation) or deep (1–2 posttetanic counts [PTC] and no twitch responses to TOF stimulation) neuromuscular blockade compared with neostigmine.

Highest recommended dose of 16 mg/kg may be used for immediate reversal of profound neuromuscular blockade induced by high-dose (1.2 mg/kg) rocuronium bromide if clinically indicated; when given shortly (approximately 3 minutes) after the onset of blockade, reduces time to recovery of neuromuscular function compared with spontaneous recovery from succinylcholine.

Effective reversal agent for steroidal neuromuscular blocking agents rocuronium and vecuronium only; do not use for reversal of nonsteroidal neuromuscular blocking agents (e.g., succinylcholine, benzylisoquinolinium compounds [atracurium, mivacurium]).

Not studied in the intensive care unit (ICU) setting.

• Generic Name: telotristat
• Dosage Forms: tablet
• Other Brand Names: Xermelo

Xermelo works by blocking the production of serotonin in the body. In people who have carcinoid syndrome, serotonin is over-produced and causes symptoms of diarrhea or frequent bowel movements, stomach pain, and flushing (warmth, redness, or tingly feeling).

Xermelo is used to treat carcinoid syndrome diarrhea.

Xermelo may also be used for purposes not listed in this medication guide.