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Sulfinpyrazone and Theochron

Determining the interaction of Sulfinpyrazone and Theochron and the possibility of their joint administration.

Check result:

Sulfinpyrazone <> Theochron

Relevance: 10.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

In one study, concomitant administration of sulfinpyrazone resulted in a 22% increase in total theophylline clearance. Changes noted in the elimination of theophylline included an increase in metabolism and a decrease in renal excretion. The clinical significance of this interaction is unknown. If sulfinpyrazone and theophylline are given together, clinical monitoring of patient response and serum theophylline levels is recommended. Patients should be advised to report worsening of their respiratory symptoms to their physician.

References

Birkett DJ, Miners JO, Attwood J "Evidence for a dual action of sulphinpyrazone on drug metabolism in man: theophylline-sulphinpyrazone interactions." Br J Clin Pharmacol 15 (1983): 567-9
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50

Sulfinpyrazone

Generic Name: sulfinpyrazone

Brand name:

Synonyms: Sulfinpyrazone (Oral)

What is Sulfinpyrazone?

Theochron

Generic Name: theophylline

Brand name: Theochron, Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: n.a.

What is Theochron?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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