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Sulfinpyrazone and Tolazamide

Determining the interaction of Sulfinpyrazone and Tolazamide and the possibility of their joint administration.

Check result:

Sulfinpyrazone <> Tolazamide

Relevance: 10.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using sulfinpyrazone together with TOLAZamide can increase the effects of TOLAZamide. You should regularly monitor your blood sugar and counseled on how to recognize and treat hypoglycemia (low blood sugar), which may include symptoms such as headache, dizziness, drowsiness, nervousness, confusion, tremor, hunger, weakness, perspiration, and palpitations. You may need a dose adjustment or blood sugar checked more often to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: The concomitant administration of pyrazolones may increase the hypoglycemic effects of sulfonylureas. Data have been variable. The proposed mechanisms include pyrazolone inhibition of sulfonylurea metabolism, inhibition of renal clearance and/or displacement from protein binding sites.

MANAGEMENT: Patients receiving this combination should be monitored for increased hypoglycemic effects and advised to regularly monitor their blood sugar, counseled on how to recognize and treat hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, tremor, hunger, weakness, or palpitations) and to notify their physician if it occurs. The sulfonylurea dosage may require reduction in affected patients.

References

Pond SM, Birkett DJ, Wade DN "Mechanisms of inhibition of tolbutamide metabolism: phenylbutazone, oxyphenbutazone, sulfaphenazole." Clin Pharmacol Ther 22 (1977): 573-9
Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344
Slade IH, and Iosefa RN "Fatal hypoglycemic coma from the use of tolbutamide in elderly patients: report of two cases." J Am Geriatr Soc 15 (1967): 948-50
Tannenbaum H, Anderson LG, Soeldner JS "Phenylbutazone-tolbutamide drug interaction." N Engl J Med 290 (1974): 344
Mahfouz M, Abdel-Maguid R, El-Dakhakhny M "Potentiation of the hypoglycaemic action of tolbutamide by different drugs." Arzneimittelforschung 20 (1970): 120-2
Eckhardt W, Rudolph R, Sauer H, Schubert WR, Undeutsch D "Zur pharmakologischen interferenz von glibornurid mit sulfaphenazol, phenylbutazon und phenprocoumon beim menschen." Arzneimittelforschung 22 (1972): 2212-9
Christensen LK, Hansen JM, Kristensen M "Sulphaphenazole-induced hypoglycemic attacks in tolbutamide-treated diabetics." Lancet 2 (1963): 1298-301
Hellman B "Potentiating effects of drugs on the binding of glibenclamide to pancreatic beta cells." Metabolism 23 (1974): 839-46
Petitpierre B, Perrin L, Rudhardt M, et al "Behaviour of chlorpropamide in renal insufficiency and under the effect of associated drug therapy." Int J Clin Pharmacol 6 (1972): 120-4
Held H, Kaminski B, von Oldersausen HF "Die beeinflussung der elimination von glycodiazin durch leber- und nierenfunctionssorungen und durch eine behandlung mit phenylbutazone, phenprocumarol und doxycyclin." Diabetologia 6 (1970): 386-91
Yu T, Berger L, Gutman AB "Hypoglycemic and uricosuric properties of acetohexamide and hydroxyhexamide." Metabolism 17 (1968): 309-16
Miners JO, Foenander T, Wanwimolruk S, Gallus AS, Birkett DJ "The effect of sulphinpyrazone on oxidative drug metabolism in man: inhibition of tolbutamide elimination." Eur J Clin Pharmacol 22 (1982): 321-6
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
Field JB, Ohta M, Boyle C, Remer A "Potentiation of acetohexamide hypoglycemia by phenylbutazone." N Engl J Med 277 (1967): 889-94
Held H, Scheible G "Interaktion von pnenylbutazon und oxyphenbutazon mit glymidin." Arzneimittelforschung 31 (1981): 1036-8
Ober KF "Mechanism of interaction of tolbutamide and phenylbutazone in diabetic patients." Eur J Clin Pharmacol 7 (1974): 291-4
Schultz E, Koch K, Schmidt FH "Ursachen der potenzierung der hypoglykamischen wirkung von sulfonylharnstoff-derivaten durch medikamente. II. Pharmakokinetik und metabolismus von glibenclamid (HB 419) in gegenwart von phenylbuazon." Eur J Clin Pharmacol 4 (1971): 32-7
Shah SJ, Bhandarkar SD, Satoskar RS "Drug interaction between chlorpropamide and non-steroidal anti-flammatory drugs, ibuprofen and phenylbutazone." Int J Clin Pharmacol Ther Toxicol 22 (1984): 470-2

Sulfinpyrazone

Generic Name: sulfinpyrazone

Brand name:

Synonyms: Sulfinpyrazone (Oral)

What is Sulfinpyrazone?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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