Sumycin and Xatmep

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Before using tetracycline, tell your doctor if you also use methotrexate. Tetracycline may increase or decrease the blood levels and side effects of methotrexate. Contact your doctor right away if you develop flu-like symptoms (fever, chills, body aches, sore throat, muscle weakness), any other signs of infection, pale skin, easy bruising or bleeding, diarrhea, or mouth sores. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Concomitant use of tetracyclines may elevate or reduce serum methotrexate concentrations. One mechanism may involve displacement of methotrexate from its binding to plasma proteins. Individual cases of methotrexate toxicity have been reported with doxycycline and tetracycline. In contrast, it has also been reported that oral antibiotics such as tetracyclines may reduce the intestinal absorption of methotrexate or interfere with its enterohepatic circulation or by inhibiting bowel flora and suppressing the metabolism of methotrexate by bacteria. However, the clinical significance of this effect has not been established.

MANAGEMENT: If these drugs must be used together, close monitoring for evidence of serious methotrexate toxicity or reduced therapeutic efficacy is recommended. If broad-spectrum antibiotic coverage is needed during high-dose methotrexate therapy, the use of an alternate anti-infective may be considered.

Sumycin

Generic Name: tetracycline

Brand name: Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap, Tetracon, Robitet 500, Emtet-500

Synonyms: n.a.

What is Sumycin?

Xatmep

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: n.a.

What is Xatmep?