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Sunitinib Malate and Torisel

Determining the interaction of Sunitinib Malate and Torisel and the possibility of their joint administration.

Check result:

Sunitinib Malate <> Torisel

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using SUNItinib together with temsirolimus may increase the risk of side effects such as severe rash, gout, and deep skin infections requiring hospitalization. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration of temsirolimus and sunitinib may increase the risk of toxicity. Dose-limiting toxicities were reported in two out of three patients in a phase I study, including grade 3/4 erythematous maculopapular rash and gout/cellulitis requiring hospitalization.

MANAGEMENT: Patients should be monitored for signs of toxicity and any reactions should be managed appropriately.

References

"Product Information. Torisel (temsirolimus)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
Cerner Multum, Inc. "Australian Product Information." O 0
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
EMEA. European Medicines Agency "EPARs. European Union Public Assessment Reports. Available from: URL: http://www.ema.europa.eu/ema/index.jsp?curl=pages/includes/medicines/medicines_landingpage.jsp&mid."

Sunitinib Malate

Generic Name: sunitinib

Brand name: Sutent

Synonyms: Sunitinib, SUNItinib

What is Sunitinib Malate?

Torisel

Generic Name: temsirolimus

Brand name: Torisel

Synonyms: n.a.

What is Torisel?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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