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Tacrine and Uniphyl

Determining the interaction of Tacrine and Uniphyl and the possibility of their joint administration.

Check result:

Tacrine <> Uniphyl

Relevance: 19.08.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with tacrine may increase the effects of theophylline. Contact your doctor if you experience nausea, vomiting, insomnia, tremors, restlessness, uneven heartbeats, and seizure (convulsions). If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADJUST DOSE: Tacrine may increase plasma theophylline levels twofold and increase the elimination half-life of theophylline. The mechanism is probably related to the fact that both agents are metabolized by CYP450 1A2. Other hepatically metabolized methylxanthines may also be affected.

MANAGEMENT: If tacrine and a theophylline must be used concomitantly, dosage reductions are recommended, as is close observation for evidence of altered clinical and laboratory effects. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians.

References

"Product Information. Cognex (tacrine)." Parke-Davis, Morris Plains, NJ.

Tacrine

Generic Name: tacrine

Brand name:

Synonyms: Tacrine (Oral)

What is Tacrine?

Uniphyl

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Uniphyl (Oral)

What is Uniphyl?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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