Tacrolimus oral and injection and Xiaflex

• Generic Name: tacrolimus
• Dosage Forms: n.a.
• Other Brand Names: Astagraf XL, Envarsus XR, Prograf, Hecoria

Tacrolimus weakens your body's immune system, to help keep it from "rejecting" a transplanted organ such as a kidney. Organ rejection happens when the immune system treats the new organ as an invader and attacks it.

Tacrolimus is used together with other medicines to prevent your body from rejecting a heart, liver, or kidney transplant.

Tacrolimus may also be used for purposes not listed in this medication guide.

• Generic Name: collagenase clostridium histolyticum
• Dosage Forms: injection
• Other Brand Names: Xiaflex

Xiaflex (collagenase clostridium histolyticum) is made from a mixture of proteins derived from a certain bacteria.

Xiaflex is used to treat Dupuytren's contracture in adults. This condition causes an abnormal thickening of the tissue in the palm of the hand. This condition may get worse over time and form a "cord" in your palm, causing a permanent bend in your finger.

Xiaflex is also used to treat a related condition called Peyronie's disease in adult men. This condition causes scar tissue or "plaque" to develop under the skin of the penis, resulting in an abnormal curving of the penis during erection.

Xiaflex is available for Peyronie's disease only from a certified pharmacy under a special program called Xiaflex REMS. You must be registered in the program and understand the risks of taking this medicine.