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Tagamet and Zovia 1/50

Determining the interaction of Tagamet and Zovia 1/50 and the possibility of their joint administration.

Check result:

Tagamet <> Zovia 1/50

Relevance: 06.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Theoretically, pharmacologic effects of estrogens may be enhanced during treatment with cimetidine due to increased serum concentrations of endogenous estradiol. The mechanism is cimetidine inhibition of the 2-hydroxylation of estradiol. In nine healthy male volunteers, the mean percentage of estradiol 2-hydroxylation decreased by 25% during a cimetidine infusion (300 mg once followed by 50 mg/hr) and by nearly 40% following two weeks of oral cimetidine (800 mg twice a day), the latter accompanied by a 20% increase in serum estradiol concentration. The interaction was also demonstrated with a lower dosage of cimetidine (400 mg orally twice a day for one week). In another study, estradiol 2-hydroxylation decreased by nearly 30% in nine premenopausal women after one month of cimetidine (800 mg orally twice a day), but there was no change in serum estradiol levels (follicular phase). In contrast, estradiol 2-hydroxylation decreased by one-half and serum estradiol levels doubled in five postmenopausal women after one month of cimetidine treatment (600 mg orally twice a day for 2 weeks, followed by 1200 mg twice a day). The clinical significance of these changes is unknown. Ranitidine (150 mg twice a day) has been shown to have no effect on estradiol metabolism or serum levels.

References

Galbraith RA, Michnovicz JJ "The oxidative metabolism of estradiol: inhibition by cimetidine." Trans Assoc Am Physicians 102 (1989): 44-54
Galbraith RA, Michnovicz JJ "The effects of cimetidine on the oxidative metabolism of estradiol." N Engl J Med 321 (1989): 269-74
Michnovicz JJ, Galbraith RA "Cimetidine inhibits catechol estrogen metabolism in women." Metabolism 40 (1991): 170-4

Tagamet

Generic Name: cimetidine

Brand name: Tagamet HB, Tagamet

Synonyms: n.a.

What is Tagamet?

Zovia 1/50

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50E

What is Zovia 1/50?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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