Tamiflu (Oseltamivir Suspension) and Trexall

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Oseltamivir may increase the blood levels and side effects of methotrexate. You may be more likely to experience this interaction if you have kidney disease or are receiving a high dose of methotrexate. The risk may be less if you are using methotrexate once a week to treat certain forms of arthritis. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor immediately if you develop symptoms of potentially serious side effects of methotrexate such as mouth ulcers or sores; vomiting; diarrhea; rash; loss of appetite; joint pain or swelling; yellow discoloration of skin and eyes; dark urine; shortness of breath; dry cough; paleness; dizziness or fainting; unusual bruising or bleeding; seizures; infection; and flu-like symptoms (fever, chills, body aches, sore throat, muscle weakness). It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Oseltamivir may inhibit the renal elimination of methotrexate. The pharmacologic effect and toxicity of methotrexate may be increased, especially in patients receiving high-dose methotrexate. The mechanism is competition for renal tubular secretion.

MANAGEMENT: If this combination must be used, European drug product labeling recommends that patients should be monitored for signs and symptoms of methotrexate toxicity; e.g., bone marrow suppression, hepatotoxicity, and nephrotoxicity. Patients should be advised to promptly report symptoms including fever, chills, sore throat, bruising, bleeding, stomatitis, malaise, shortness of breath, lower extremity edema, jaundice, or change in stool or urine color to their physician.

Tamiflu (Oseltamivir Suspension)

Generic Name: oseltamivir

Brand name: Tamiflu

Synonyms: Tamiflu

What is Tamiflu (Oseltamivir Suspension)?

Trexall

Generic Name: methotrexate

Brand name: Rheumatrex Dose Pack, Trexall, Xatmep, Otrexup, Rasuvo, Methotrexate Sodium, Preservative Free

Synonyms: n.a.

What is Trexall?