Targretin and Tolazamide

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using bexarotene together with insulin or certain other diabetes medications may increase the risk of hypoglycemia, or low blood sugar. Symptoms of low blood sugar include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, sweating, and fast or pounding heartbeats. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Talk to your doctor or pharmacist if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The hypoglycemic effect of insulin and certain other antidiabetic agents (e.g., sulfonylureas, thiazolidinediones) may theoretically be potentiated by bexarotene. Bexarotene may increase the risk of hypoglycemia by enhancing insulin sensitivity and/or stimulating insulin secretion. Clinical hypoglycemia has not been reported during use of bexarotene as monotherapy.

MANAGEMENT: Close monitoring for the development of hypoglycemia is recommended if bexarotene is coadministered with insulin or another antidiabetic agent, particularly in patients with advanced age and/or renal impairment. The oral antidiabetic or insulin dosage(s) may require adjustment if an interaction is suspected. Patients should be apprised of the signs and symptoms of hypoglycemia (e.g., headache, dizziness, drowsiness, nausea, hunger, tremor, weakness, sweating, palpitations), how to treat it, and to contact their doctor if it occurs. Patients should be observed for loss of glycemic control when bexarotene is withdrawn.

Targretin

Generic Name: bexarotene

Brand name: Targretin

Synonyms: n.a.

What is Targretin?

Tolazamide

Generic Name: tolazamide

Brand name: Tolinase

Synonyms: TOLAZamide

What is Tolazamide?