Targretin and Verapamil Long-Acting Tablets
Determining the interaction of Targretin and Verapamil Long-Acting Tablets and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.
Professional:Coadministration with inhibitors of CYP450 3A4 may theoretically increase the plasma concentrations of bexarotene. In vitro studies suggest that bexarotene is metabolized by CYP450 3A4. However, concomitant administration with multiple doses of ketoconazole, a potent CYP450 3A4 inhibitor, did not alter bexarotene plasma concentrations, which would imply that bexarotene elimination is not substantially dependent on CYP450 3A4 metabolism in vivo. Conversely, bexarotene appears to be an inducer of CYP450 3A4 and may reduce the plasma concentrations of CYP450 3A4 inhibitors that are also substrates of the isoenzyme, such as azole antifungals, macrolides, some calcium channel blockers, mifepristone, and nefazodone. The clinical significance is unknown.
- "Product Information. Targretin (bexarotene)" Ligand Pharmaceuticals, San Diego, CA.
Generic Name: verapamil
Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM
Synonyms: Verapamil
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Targretin-Verapamil oral/injection
- Targretin-Verapamil Sustained-Release Capsules
- Targretin-Verdeso
- Targretin-Verdrocet
- Targretin-Verelan
- Targretin-Verelan PM
- Verapamil Long-Acting Tablets-Targretin (Bexarotene (Systemic))
- Verapamil Long-Acting Tablets-Targretin (Bexarotene (Topical))
- Verapamil Long-Acting Tablets-Targretin Gel
- Verapamil Long-Acting Tablets-Targretin topical
- Verapamil Long-Acting Tablets-Tarina 24 Fe
- Verapamil Long-Acting Tablets-Tarina Fe 1/20