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Tarina Fe 1/20 and Teriflunomide

Determining the interaction of Tarina Fe 1/20 and Teriflunomide and the possibility of their joint administration.

Check result:
Tarina Fe 1/20 <> Teriflunomide
Relevance: 12.11.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Talk to your doctor before using teriflunomide together with ethinyl estradiol. Combining these medications may increase the blood levels and effects of some hormone-based medications. The risk of side effects such as insulin resistance, lipid disorders, acne, and blood clots may increase. Talk to your gynecologist or other healthcare professional for help in selecting effective methods of birth control or hormone replacement that work best for you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with teriflunomide may increase the plasma concentrations of contraceptive hormones. The mechanism of interaction has not been described. In study subjects, ethinyl estradiol peak plasma concentration (Cmax) and systemic exposure (AUC) increased by approximately 1.5-fold each, and levonorgestrel Cmax and AUC increased by approximately 1.3- and 1.4-fold, respectively, following repeated doses of teriflunomide.

MANAGEMENT: Caution is advised if teriflunomide is prescribed in patients receiving hormonal contraceptives due to the potential for increased adverse effects such as thromboembolism. Consideration should be given to the type or dose of contraceptives used in combination with teriflunomide.

References
  • "Product Information. Aubagio (teriflunomide)." Genzyme Corporation, Cambridge, MA.
Tarina Fe 1/20

Generic Name: ethinyl estradiol / norethindrone

Brand name: Blisovi 24 Fe, Blisovi Fe 15/30, Blisovi Fe 1/20, Estrostep Fe, Gildess 24 Fe, Gildess Fe 15/30, Gildess Fe 1/20, Junel Fe 15/30, Junel Fe 1/20, Junel Fe 24, Larin 24 Fe, Larin Fe 15/30, Larin Fe 1/20, Lo Loestrin Fe, Loestrin 24 Fe, Loestrin Fe 15/30, Loestrin Fe 1/20, Lomedia 24 Fe, Microgestin 24 Fe, Microgestin Fe 15/30, Microgestin Fe 1/20, Tarina Fe 1/20, Taytulla, Tilia Fe, Tri-Legest Fe, Blisovi 24 Fe, Femcon Fe, Kaitlib FE, Lo Minastrin Fe, Microgestin 24 Fe, Norinyl 1+35, Ortho-Novum 7/7/7, Tri-Norinyl, Zenchent, femhrt 05 mg/25 mcg, Fyavolv, Jevantique Lo, Jinteli, Femcon Fe, Generess FE, Loestrin 1/20, Ovcon 35, Brevicon

Synonyms: n.a.

Teriflunomide

Generic Name: teriflunomide

Brand name: Aubagio

Synonyms: n.a.

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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Disease interaction