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Tegretol and Tezacaftor/ivacaftor and ivacaftor

Determining the interaction of Tegretol and Tezacaftor/ivacaftor and ivacaftor and the possibility of their joint administration.

Check result:

Tegretol <> Tezacaftor/ivacaftor and ivacaftor

Relevance: 23.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using ivacaftor together with carBAMazepine is generally not recommended. Combining these medications may significantly decrease the blood levels of ivacaftor, which may make the medication less effective in the treatment of cystic fibrosis. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ivacaftor, which is primarily metabolized by the isoenzyme. In study subjects, administration of a single 150 mg dose of ivacaftor with the potent CYP450 3A4 inducer rifampin (600 mg once daily) decreased ivacaftor peak plasma concentration (Cmax) and systemic exposure (AUC) by 80% and 89%, respectively, compared to administration of ivacaftor alone. When lumacaftor/ivacaftor was coadministered with rifampin, lumacaftor pharmacokinetics were minimally affected, but ivacaftor Cmax and AUC decreased by an average of 50% and 57%, respectively. No pharmacokinetic data are available for elexacaftor or tezacaftor, but decreased exposures are expected according to prescribing information.

MANAGEMENT: Concomitant use of ivacaftor-containing medications with potent CYP450 3A4 inducers is not recommended.

References

Cerner Multum, Inc. "Australian Product Information." O 0
"Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
"Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
"Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
"Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

Tezacaftor/ivacaftor and ivacaftor

Generic Name: ivacaftor / tezacaftor

Brand name: Symdeko, Symdeko 4-Week

Synonyms: Tezacaftor/ivacaftor and ivacaftor (Oral)

What is Tezacaftor/ivacaftor and ivacaftor?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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