Tegretol and Triaminic Multi-Symptom Fever
Determining the interaction of Tegretol and Triaminic Multi-Symptom Fever and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using acetaminophen together with carBAMazepine may alter the effects of acetaminophen and cause serious side effects that may affect your liver. Call your doctor immediately if you experience a fever, chills, joint pain or swelling, excessive tiredness or weakness, unusual bleeding or bruising, skin rash or itching, loss of appetite, nausea, vomiting, or yellowing of the skin or the whites of your eyes. If your doctor does prescribe these medications together, you may need a dose adjustment or special tests to safely take both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Limited data suggest that carbamazepine may increase the potential hepatotoxicity of acetaminophen and decrease its pharmacologic effects. The mechanism may be related to accelerated CYP450 metabolism of acetaminophen with consequent increase of hepatotoxic metabolites. This interaction is of greatest concern in cases of acetaminophen overdose.
MANAGEMENT: Until more information is available, the use of this combination over a prolonged period of time should probably be avoided. Monitoring for clinical and laboratory evidence of hepatotoxicity is recommended.
- Miners JO, Attwood J, Birkett DJ "Determinants of acetaminophen metabolism: effect of inducers and inhibitors of drug metabolism on acetaminophen's metabolic pathways." Clin Pharmacol Ther 35 (1984): 480-6
- Perucca E, Richens A "Paracetamol disposition in normal subjects and in patients treated with antiepileptic drugs." Br J Clin Pharmacol 7 (1979): 201-6
- Smith JA, Hine ID, Beck P, Routledge PA "Paracetamol toxicity: is enzyme induction important?" Hum Toxicol 5 (1986): 383-5
Generic Name: carbamazepine
Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR
Synonyms: n.a.
Generic Name: acetaminophen / chlorpheniramine / dextromethorphan
Brand name: Coricidin HBP Maximum Strength Flu, Nyquil Cold & Flu, Triaminic Flu Cough & Fever, Triaminic Multi-Symptom Fever, Tylenol Childrens Plus Cough & Runny Nose, Coricidin II Extra Strength Cold and Flu, Mapap Cough & Sinus Formula, Children's Tylenol Cold + Cough + Runny Nose, Children's Triaminic Flu Cough & Fever, Vicks Formula 44 Custom Care Cough/Cold PM
Synonyms: Triaminic Flu Cough & Fever
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Tegretol-Triaminic Night Time Cold & Cough
- Tegretol-Triaminic Softchew Throat Pain and Cough
- Tegretol-Triaminic Softchews Allergy Congestion
- Tegretol-Triaminic Softchews Allergy Sinus
- Tegretol-Triaminic Softchews Chest Congestion
- Tegretol-Triaminic Softchews Cough & Sore Throat (pseudoephedrine)
- Triaminic Multi-Symptom Fever-Tegretol (Carbamazepine Chewable Tablets)
- Triaminic Multi-Symptom Fever-Tegretol (Carbamazepine Oral Suspension)
- Triaminic Multi-Symptom Fever-Tegretol (Carbamazepine Tablets)
- Triaminic Multi-Symptom Fever-Tegretol XR
- Triaminic Multi-Symptom Fever-Tegrin Medicated
- Triaminic Multi-Symptom Fever-Tegsedi