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Tegretol and Uniphyl

Determining the interaction of Tegretol and Uniphyl and the possibility of their joint administration.

Check result:

Tegretol <> Uniphyl

Relevance: 23.06.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using carBAMazepine together with theophylline may decrease the effects of theophylline. Contact your doctor if your condition change or if you experience a worsening of breathing problems, If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Carbamazepine may decrease theophylline serum levels. Also, theophyllines may decrease serum levels and effects of carbamazepine. The mechanisms may be related to induction of hepatic CYP450 metabolism.

MANAGEMENT: Close observation for clinical and laboratory evidence of altered effects is recommended for both agents. Patients should be advised to notify their physician if they experience loss of therapeutic effects.

References

Mitchell EA "Interaction between carbamazinepine and theophylline." N Z Med J 1 (1986): 69-70
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Rosenberry KR, Defusco CJ, Mansmann HC, McGeady SJ "Reduced theophylline half-life induced by carbamazepine therapy." J Pediatr 102 (1983): 472-4

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

Uniphyl

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Uniphyl (Oral)

What is Uniphyl?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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