Tegretol and Viekira

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using ombitasvir together with carBAMazepine is not recommended. Combining these medications may significantly reduce the blood levels of ombitasvir, which may make the medication less effective in treating hepatitis C. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

CONTRAINDICATED: Coadministration with potent inducers of CYP450 isoenzymes may significantly decrease the plasma concentrations of ombitasvir, paritaprevir, ritonavir, and dasabuvir. In 12 study subjects, administration of single-dose ombitasvir, paritaprevir, ritonavir, and dasabuvir with the potent CYP450 inducer carbamazepine (200 mg once daily followed by 200 mg twice daily) decreased ombitasvir peak plasma concentration (Cmax) by 31% and systemic exposure (AUC) by 31%; paritaprevir Cmax by 66% and AUC by 70%; ritonavir Cmax by 83% and AUC by 87%; and dasabuvir Cmax by 55% and AUC by 70%. Loss of therapeutic effects and development of resistance may occur.

MANAGEMENT: Concomitant use of ombitasvir/paritaprevir/ritonavir plus dasabuvir with potent CYP450 inducers such as carbamazepine, phenobarbital, phenytoin, rifampin, and St. John's wort is considered contraindicated.

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

Viekira

Generic Name: dasabuvir / ombitasvir / paritaprevir / ritonavir

Brand name: Viekira XR, Viekira Pak

Synonyms: Ombitasvir, Paritaprevir, Ritonavir, and Dasabuvir Extended-Release Tablets, and Dasabuvir

What is Viekira?