Tegretol and Vilazodone Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

CarBAMazepine may reduce the blood levels and effects of vilazodone. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

ADJUST DOSE: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of vilazodone, which is primarily metabolized by the isoenzyme. According to the product labeling, concomitant use of vilazodone with potent CYP450 3A4 inducers such as carbamazepine can decrease vilazodone systemic exposure by approximately 45%.

MANAGEMENT: The possibility of diminished therapeutic response to vilazodone should be considered during coadministration with potent CYP450 3A4 inducers such as carbamazepine, enzalutamide, phenobarbital, phenytoin, and rifampin. When concomitant use is prescribed for greater than 14 days, an increase in the vilazodone dosage up to 2-fold may be considered depending on clinical response, up to a maximum of 80 mg daily. Following discontinuation of the CYP450 3A4 inducer, the dosage of vilazodone should be returned to the original level in 14 days.

Tegretol

Generic Name: carbamazepine

Brand name: Carbatrol, Epitol, Equetro, Tegretol, Tegretol XR, Tegretol, Tegretol XR

Synonyms: n.a.

What is Tegretol?

Vilazodone Hydrochloride

Generic Name: vilazodone

Brand name: Viibryd, Viibryd Starter

Synonyms: Vilazodone

What is Vilazodone Hydrochloride?