Tekturna and Tolsura

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using aliskiren together with itraconazole is not recommended. Combining these medications can significantly increase the blood levels and effects of aliskiren. This may cause an excessive fall in blood pressure and increase the risk of a condition called hyperkalemia (high blood potassium), which in severe cases can lead to kidney failure, muscle paralysis, irregular heart rhythm, and cardiac arrest. You may be more likely to develop hyperkalemia while taking aliskiren if you are elderly, dehydrated, or have kidney disease, diabetes, or advanced heart failure. Regular or long-term use of nonsteroidal anti-inflammatory drugs such as ibuprofen or naproxen (Aleve) may also increase your risk. It is important that you maintain adequate fluid intake during treatment with aliskiren. In addition, talk to your doctor to see if you should limit consumption of potassium-rich foods such as tomatoes, raisins, figs, potatoes, lima beans, bananas, plantains, papayas, pears, cantaloupes, mangoes, and potassium-containing salt substitutes. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat, as these may be symptoms of hyperkalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with itraconazole may significantly increase the plasma concentrations of aliskiren, a renin inhibitor. The proposed mechanism is itraconazole inhibition of the intestinal efflux of aliskiren via P-glycoprotein, with a minor contribution from inhibition of CYP450 3A4. In 11 healthy volunteers, itraconazole 100 mg (first dose 200 mg) administered twice daily for 5 days in combination with a single 150 mg dose of aliskiren on day 3 resulted in a 5.8-fold increase in aliskiren peak plasma concentration (Cmax) and a 6.5-fold increase in systemic exposure (AUC). Coadministration with itraconazole also increased the urinary excretion of aliskiren over a 12-hour period by 8.0-fold and its renal clearance by 1.2-fold. In addition, plasma renin activity 24 hours after aliskiren intake was 68% lower with itraconazole than with placebo. There was no significant effect of itraconazole on the elimination half-life of aliskiren.

MANAGEMENT: Concomitant use of aliskiren with itraconazole is not recommended.

Tekturna

Generic Name: aliskiren

Brand name: Tekturna

Synonyms: n.a.

What is Tekturna?

Tolsura

Generic Name: itraconazole

Brand name: Onmel, Sporanox, Sporanox PulsePak, Tolsura

Synonyms: n.a.

What is Tolsura?