Telaprevir and Tracleer (Bosentan Tablets for Oral Suspension)

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using telaprevir together with bosentan. Combining these medications may decrease the blood levels of telaprevir, which may reduce its effectiveness in treating hepatitis C. At the same time, telaprevir may cause the blood levels of bosentan to increase. You may be more likely to experience side effects of bosentan such as nausea, vomiting, fatigue, headache, low blood pressure, fluid retention, anemia, and liver damage. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop fainting; sudden, unexplained weight gain; swelling of the legs or ankles; chest pain; or difficulty breathing during treatment with these medications. You should also seek medical attention if you experience potential signs and symptoms of liver damage such as fever, rash, loss of appetite, nausea, vomiting, fatigue, upper abdominal pain, dark urine, or yellowing of the skin and eyes. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration of bosentan with boceprevir or telaprevir is expected to increase the plasma concentrations of bosentan and decrease the plasma concentrations of the hepatitis C virus (HCV) NS3/4A protease inhibitor. The proposed mechanism involves inhibition of bosentan metabolism via CYP450 3A4 and, conversely, induction of boceprevir and telaprevir metabolism via the same isoenzyme. The interaction has not been specifically studied with either boceprevir or telaprevir, but has been reported with HIV protease inhibitors.

MANAGEMENT: Caution is recommended if bosentan is used in combination with boceprevir or telaprevir. The possibility of prolonged and/or increased pharmacologic effects of bosentan, including serious adverse effects such as hepatotoxicity, should also be considered. Patients should be advised to notify their physician if they experience signs and symptoms of hepatotoxicity such as fever, rash, anorexia, nausea, vomiting, fatigue, right upper quadrant pain, dark urine, and jaundice. Close clinical monitoring of the virologic response to the HCV NS3/4A protease inhibitor is also appropriate.

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?

Tracleer (Bosentan Tablets for Oral Suspension)

Generic Name: bosentan

Brand name: Tracleer

Synonyms: Tracleer

What is Tracleer (Bosentan Tablets for Oral Suspension)?