Telaprevir and Vfend

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Talk to your doctor before using voriconazole together with telaprevir. Combining these medications may alter the blood levels and effects of both. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

GENERALLY AVOID: Coadministration with voriconazole may increase the plasma concentrations of telaprevir. The mechanism involves voriconazole inhibition of CYP450 3A4, the isoenzyme primarily responsible for the metabolic clearance of telaprevir. The interaction has not been specifically studied with voriconazole, but has been reported with another azole antifungal agent. In 17 study subjects, administration of a single 750 mg dose of telaprevir in combination with a single 400 mg dose of ketoconazole resulted in an average 24% increase in telaprevir peak plasma concentration (Cmax) and 62% increase in systemic exposure (AUC) compared to administration alone. The effect of telaprevir on the pharmacokinetics of voriconazole is unknown. Because telaprevir is also an inhibitor of CYP450 3A4, it may increase the plasma concentrations of voriconazole. However, due to multiple isoenzymes involved in voriconazole metabolism, the potential interaction with telaprevir is difficult to predict.

MANAGEMENT: Voriconazole should not be administered to patients receiving telaprevir unless the benefits are anticipated to outweigh the risks.

Telaprevir

Generic Name: telaprevir

Brand name: Incivek

Synonyms: Telaprevir (Oral)

What is Telaprevir?

Vfend

Generic Name: voriconazole

Brand name: Vfend, Vfend

Synonyms: Vfend Injection

What is Vfend?