Telotristat Etiprate and Zonalon

• Generic Name: telotristat
• Dosage Forms: n.a.
• Other Brand Names: Xermelo

Used (in combination with somatostatin analog therapy) for treatment of carcinoid syndrome diarrhea inadequately controlled by somatostatin analog therapy alone (designated an orphan drug by FDA for the treatment of carcinoid syndrome in patients with neuroendocrine tumors).

Carcinoid syndrome, a condition associated with serotonin overproduction, is characterized by flushing, diarrhea, wheezing, occasionally congestive heart failure, and various other manifestations. Although somatostatin analogs (e.g., octreotide, lanreotide) are standard treatment for carcinoid syndrome and are effective initially in most patients, some patients may not respond adequately or may develop recurrent symptoms, including diarrhea, despite therapy.

In clinical studies, telotristat ethyl reduced the frequency of daily bowel movements in patients with carcinoid syndrome diarrhea. Reductions in other symptoms of carcinoid syndrome (e.g., abdominal pain, flushing) not observed.

• Generic Name: doxepin topical
• Dosage Forms: cream
• Other Brand Names: Prudoxin, Zonalon

Doxepin is a tricyclic antidepressant. When applied to the skin, Zonalon can help relieve itching but it will not treat symptoms of depression.

Zonalon (for use on skin) is used to treat itchy skin in adults with eczema or other skin conditions that can lead to repeated scratching and thickened skin.

Zonalon may also be used for purposes not listed in this medication guide.