Teriflunomide and Warfarin

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Warfarin may alter the blood-thinning effects of teriflunomide. You may need more frequent monitoring of your prothrombin time or INR by your doctor to safely use both medications. Let your doctor know if your condition changes or you experience unusual bleeding or bruising. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with teriflunomide may alter the hypoprothrombinemic effects of warfarin. The mechanism of interaction has not been described, and no pharmacokinetic data are currently available. A 25% decrease in peak INR was observed when teriflunomide was coadministered with warfarin as compared to warfarin alone.

MANAGEMENT: Caution is advised if teriflunomide is prescribed in combination with warfarin or similar anticoagulants. The INR may need to be monitored more closely following addition or discontinuation of teriflunomide, and the warfarin dosage adjusted as necessary.

Teriflunomide

Generic Name: teriflunomide

Brand name: Aubagio

Synonyms: n.a.

What is Teriflunomide?

Warfarin

Generic Name: warfarin

Brand name: Coumadin, Jantoven

Synonyms: n.a.

What is Warfarin?