Tezacaftor and Ivacaftor and Zolpidem Oral Spray
Determining the interaction of Tezacaftor and Ivacaftor and Zolpidem Oral Spray and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Consumer information for this interaction is not currently available.MONITOR: Coadministration with ivacaftor may increase the plasma concentrations of drugs that are substrates of the CYP450 2C9 isoenzyme. The proposed mechanism, based on in vitro data, involves decreased metabolic clearance due to inhibition of CYP450 2C9 by ivacaftor. The clinical relevance is unknown. MANAGEMENT: Caution is advised when ivacaftor is used concurrently with drugs that are known CYP450 2C9 substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ivacaftor is added to or withdrawn from therapy. References "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA. "Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA. "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA. "Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA. View all 4 references
Professional:MONITOR: Coadministration with ivacaftor may increase the plasma concentrations of drugs that are substrates of the CYP450 2C9 isoenzyme. The proposed mechanism, based on in vitro data, involves decreased metabolic clearance due to inhibition of CYP450 2C9 by ivacaftor. The clinical relevance is unknown.
MANAGEMENT: Caution is advised when ivacaftor is used concurrently with drugs that are known CYP450 2C9 substrates, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring may be appropriate for some drugs whenever ivacaftor is added to or withdrawn from therapy.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Trikafta (elexacaftor/ivacaftor/tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Generic Name: ivacaftor / tezacaftor
Brand name: Symdeko, Symdeko 4-Week
Synonyms: Ivacaftor and tezacaftor
Generic Name: zolpidem
Brand name: Ambien, Ambien CR, Edluar, Intermezzo, ZolpiMist
Synonyms: Zolpidem
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Tezacaftor and Ivacaftor-Zolpidem Oral, Oromucosal
- Tezacaftor and Ivacaftor-Zolpidem Sublingual
- Tezacaftor and Ivacaftor-Zolpidem Sublingual Tablets (Edluar)
- Tezacaftor and Ivacaftor-Zolpidem Sublingual Tablets (Intermezzo)
- Tezacaftor and Ivacaftor-Zolpidem Tablets
- Tezacaftor and Ivacaftor-Zolpidem Tartrate
- Zolpidem Oral Spray-Tezacaftor/ivacaftor and ivacaftor
- Zolpidem Oral Spray-TGQ 30PSE/3BRM/15DM
- Zolpidem Oral Spray-TGQ 7.5PEH/4BRM/15DM
- Zolpidem Oral Spray-TGT First Aid Antibiotic
- Zolpidem Oral Spray-TGT First Aid Cleansing
- Zolpidem Oral Spray-TH Antibiotic + Pain Relief