Thalomid and Zometa

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Using thalidomide together with zoledronic acid may increase your risk of developing kidney problems. Symptoms of kidney damage include swelling, weight gain, feeling short of breath, drowsiness, confusion, mood changes, increased thirst, loss of appetite, nausea and vomiting, pain in your lower back, and urinating more or less than usual or not at all. If you take both medications together, tell your doctor if you have any of these symptoms. You may need a dose adjustment or special tests to safely use these medications together. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: In multiple myeloma patients, the risk of renal dysfunction may be increased when intravenous bisphosphonates are used in combination with thalidomide. The mechanism of interaction has not been described.

MANAGEMENT: Caution is advised if pamidronate, zoledronic acid, or other intravenous formulations of bisphosphonates must be used in multiple myeloma patients who are receiving treatment with thalidomide. Renal function and serum electrolytes should be monitored. Product labelings for pamidronate and zoledronic acid recommend that single doses not exceed 90 mg and 4 mg, respectively, and the duration of infusion not less than 2 hours and 15 minutes, respectively. Patients should have serum creatinine assessed prior to each treatment, and treatment should be withheld for renal deterioration. In those treated for bone metastases, treatment should not be resumed until renal function returns to baseline.

Thalomid

Generic Name: thalidomide

Brand name: Thalomid

Synonyms: n.a.

What is Thalomid?

Zometa

Generic Name: zoledronic acid

Brand name: Reclast, Zometa, Aclasta, Zometa Concentrate

Synonyms: n.a.

What is Zometa?