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Theo-Dur and Ticlopidine

Determining the interaction of Theo-Dur and Ticlopidine and the possibility of their joint administration.

Check result:

Theo-Dur <> Ticlopidine

Relevance: 06.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using theophylline together with ticlopidine may alter the effects of both medications. Contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat. If your doctor does prescribe these medications together, you may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: In one study, theophylline clearance was reduced by 37% and theophylline half-life increased by 42% during concomitant ticlopidine therapy. The exact mechanism of this interaction is not known, but ticlopidine probably interferes with theophylline metabolism.

MANAGEMENT: Theophylline levels and clinical response should be monitored when ticlopidine therapy is initiated or discontinued. Patients should be advised to report any signs of theophylline toxicity during concurrent therapy, including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References

Colli A, Buccino G, Cocciolo M, Parravicini R, Elli GM, Scaltrini G "Ticlopidine-theophylline interaction." Clin Pharmacol Ther 41 (1987): 358-62

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

Ticlopidine

Generic Name: ticlopidine

Brand name: Ticlid

Synonyms: n.a.

What is Ticlopidine?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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