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Theo-Dur and Trental

Determining the interaction of Theo-Dur and Trental and the possibility of their joint administration.

Check result:

Theo-Dur <> Trental

Relevance: 06.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Pentoxifylline may increase the blood levels and effects of theophylline. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if you develop nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, heart palpitation, and/or irregular heartbeat, as these may be signs and symptoms of excessive theophylline levels. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Coadministration with pentoxifylline may increase the serum concentrations of theophylline. The mechanism of interaction has not been described, but may involve competitive metabolism as both drugs are methylxanthine derivatives. In nine healthy volunteers, mean serum theophylline trough concentration increased by 30% when theophylline (300 mg SR twice a day) was coadministered with pentoxifylline (400 mg three times a day) for 7 days. Studies indicate no interference with theophylline assays by pentoxifylline and its metabolites, although unusually high pentoxifylline serum concentrations have been reported when an enzyme-multiplied immunoassay (EMIT) is used.

MANAGEMENT: Caution is advised if theophylline preparations are used in combination with pentoxifylline. Serum theophylline concentrations should be monitored more closely following the initiation, discontinuation or change of dosage of pentoxifylline, and the theophylline dosage adjusted as necessary.

References

Cohen IA, Johnson CE, Wesolowicz L, Converse-Swastek K "Effect of pentoxifylline and its metabolites on three theophylline assays." Clin Pharm 7 (1988): 457-61
"Product Information. Trental (pentoxifylline)." Hoechst Marion-Roussel Inc, Kansas City, MO.
Cummings DM, Rocci ML Jr, Green P, Saccar C "Interference potential of pentoxifylline and its major metabolite with theophylline assays." Am J Hosp Pharm 42 (1985): 2717-8
Ellison MJ, Horner RD, Willis SE, Cummings DM "Influence of pentoxifylline on steady-state theophylline serum concentrations from sustained-release formulations." Pharmacotherapy 10 (1990): 383-6

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

Trental

Generic Name: pentoxifylline

Brand name: Trental, Pentoxil

Synonyms: n.a.

What is Trental?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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