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Theo-Dur and Verapamil Sustained-Release Capsules

Determining the interaction of Theo-Dur and Verapamil Sustained-Release Capsules and the possibility of their joint administration.

Check result:

Theo-Dur <> Verapamil Sustained-Release Capsules

Relevance: 06.06.2023 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Using verapamil together with theophylline can increase the effects of theophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

MONITOR: Verapamil may increase theophylline serum levels, theophylline effect, and risk of toxicity. The mechanism is inhibition of CYP450 hepatic metabolism by verapamil. Other hepatically metabolized methylxanthines may also be affected. Cigarette smokers appear to have a greater risk of developing theophylline toxicity from this combination.

MANAGEMENT: Clinical monitoring of patient response and tolerance and serum theophylline levels is recommended. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physicians. Theophylline dosage should be reduced as appropriate. Isradipine and nifedipine appear to have minimal effects on theophylline pharmacokinetics.

References

Stringer KA, Mallet J, Clarke M, Lindenfield JA "The effect of three different oral doses of verapamil on the disposition of theophylline." Eur J Clin Pharmacol 43 (1992): 35-8
McTavish D, Sorkin EM "Verapamil: an updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension." Drugs 38 (1989): 19-76
Gin AS, Stringer KA, Welage LS, et al "The efect of verapamil on the pharmacokinetic disposition of theophylline in cigarette smokers." J Clin Pharmacol 29 (1989): 728-32
Taniguchi A, Ohe T, Shimorura K "Theophylline-induced ventricular tachycardia in a patient with chronic lung disease: sensitivity to verapamil." Chest 96 (1989): 958-9
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Abernethy DR, Egan JM, Dickinson TH, Carrum G "Substrate-selective inhibition by verapamil and diltiazem: differential disposition of antipyrine and theophylline in humans." J Pharmacol Exp Ther 244 (1988): 994-9
Fuhr U, Woodcock BG, Siewart M "Verapamil and drug metabolism by the cytochrome p450 isoform CYP1A2." Eur J Clin Pharmacol 42 (1992): 463-4
Nielsen-Kudsk JE, Buhl JS, Johannessen AC "Verapamil-induced inhibition of theophylline elimination in healthy humans." Pharmacol Toxicol 66 (1990): 101-3

Theo-Dur

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theo-Dur (Oral)

What is Theo-Dur?

Verapamil Sustained-Release Capsules

Generic Name: verapamil

Brand name: Calan, Isoptin SR, Verelan, Isoptin, Calan SR, Isoptin IV, Covera-HS, Verelan PM

Synonyms: Verapamil

What is Verapamil Sustained-Release Capsules?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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