Theophylline and guaifenesin and Vibramycin (Doxycycline Syrup)
Determining the interaction of Theophylline and guaifenesin and Vibramycin (Doxycycline Syrup) and the possibility of their joint administration.
In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.
Consumer:Using doxycycline together with theophylline may increase the effects of theophylline. You should contact your doctor if you experience nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or an irregular heartbeat. You may need a dose adjustment or special test to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Professional:MONITOR: Coadministration of a tetracycline may decrease theophylline plasma clearance and increase theophylline levels. The mechanism is unknown. Data are available for minocycline, tetracycline, and doxycycline, but are conflicting in some cases. This interaction appears to be more problematic if a tetracycline is administered for more than five days. Patients with chronic obstructive pulmonary disease, congestive heart failure, or cirrhosis may have slower theophylline clearance rates; therefore, they may be at greater risk of developing theophylline toxicity.
MANAGEMENT: If these drugs are given concurrently, close clinical and laboratory monitoring of response and tolerance is recommended. Patients should be advised to notify their physician if they experience any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, seizures, or irregular heartbeats. It may be necessary to reduce theophylline dosage.
- Gotz VP, Ryerson GG "Evaluation of tetracycline on theophylline disposition in patients with chronic obstructive airways disease." Drug Intell Clin Pharm 20 (1986): 694-6
- McCormack JP, Reid SE, Lawson LM "Theophylline toxicity induced by tetracycline." Clin Pharm 9 (1990): 546-9
- Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part I)." Clin Pharmacokinet 20 (1991): 66-80
Generic Name: guaifenesin / theophylline
Brand name:
Synonyms: Theophylline and guaifenesin (Oral)
Generic Name: doxycycline
Brand name: Vibramycin, Acticlate, Adox Pak 2/100, Adoxa, Adoxa Pak 1/100, Adoxa Pak 1/150, Avidoxy, Monodox, Morgidox, Oraxyl, TargaDOX, Adoxa CK, Adoxa Pak, Adoxa TT, Alodox, Avidoxy, Doryx, Mondoxyne NL, Oracea, Periostat Targadox, Vibramycin Calcium, Vibramycin Hyclate, Vibramycin monohydrate, Vibra-Tabs, Doxy 100, TargaDOX
Synonyms: Vibramycin (Suspension), Vibramycin
In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.
- Theophylline and guaifenesin-Vibramycin (Doxycycline Tablets and Capsules)
- Theophylline and guaifenesin-Vibramycin Calcium
- Theophylline and guaifenesin-Vibramycin Hyclate
- Theophylline and guaifenesin-Vicks 44 Cold, Flu and Cough
- Theophylline and guaifenesin-Vicks 44 Cough Relief
- Theophylline and guaifenesin-Vicks DayQuil Multi-Symptom
- Vibramycin (Doxycycline Syrup)-Theophylline Elixir
- Vibramycin (Doxycycline Syrup)-Theophylline in Dextrose
- Vibramycin (Doxycycline Syrup)-Theophylline Injection
- Vibramycin (Doxycycline Syrup)-Theophylline Intravenous
- Vibramycin (Doxycycline Syrup)-Theophylline Liquid
- Vibramycin (Doxycycline Syrup)-Theophylline Oral Solution