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Theophylline Injection and Xanax

Determining the interaction of Theophylline Injection and Xanax and the possibility of their joint administration.

Check result:

Theophylline Injection <> Xanax

Relevance: 04.05.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Methylxanthines may antagonize the sedative effects of benzodiazepines. Aminophylline in particular has been demonstrated to attenuate the sedative effects of diazepam. The mechanism of this interaction may be related to competitive binding to intracerebral adenosine receptors. One study demonstrated that alprazolam serum concentrations were significantly lower in patients receiving chronic theophylline therapy than in patients not receiving theophylline. Clinical and laboratory monitoring is warranted if these agents are given concurrently. Patients receiving this combination should be monitored for adequate response to the benzodiazepine.

References

Tuncok Y, Akpinar O, Guven H, Akkoclu A "The effects of theophylline on serum alprazolam levels." Int J Clin Pharmacol Ther 32 (1994): 642-5
Bonfiglio MF, Dasta JF "Clinical significance of the benzodiazepine-theophylline interaction." Pharmacotherapy 11 (1991): 85-7
Stirt JA "Aminophylline is a diazepam antagonist." Anesth Analg 60 (1981): 767-8
Upton RA "Pharmacokinetic interactions between theophylline and other medication (Part II)." Clin Pharmacokinet 20 (1991): 135-50
Gallen JS "Aminophylline reversal of midazolam sedation." Anesth Analg 69 (1989): 268

Theophylline Injection

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theophylline

What is Theophylline Injection?

Xanax

Generic Name: alprazolam

Brand name: Niravam, Xanax, Xanax XR, Alprazolam Intensol

Synonyms: n.a.

What is Xanax?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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