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Theophylline Liquid and Tocainide

Determining the interaction of Theophylline Liquid and Tocainide and the possibility of their joint administration.

Check result:

Theophylline Liquid <> Tocainide

Relevance: 12.11.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Consumer information for this minor interaction is not currently available. Some minor drug interactions may not be clinically relevant in all patients. Minor drug interactions do not usually cause harm or require a change in therapy. However, your healthcare provider can determine if adjustments to your medications are needed.

Professional:

Tocainide causes a decrease in theophylline clearance. The result is an increase in serum theophylline concentrations and a mild increase in the serum half-life of theophylline. The magnitude of this interaction is less than for mexiletine, which has been shown to reduce theophylline plasma clearance by 40% to 45%. The mechanism of this interaction is not known. Tocainide may interact in a similar way with other xanthines. Management consists of monitoring clinical status during therapy and checking serum theophylline levels as necessary. Patients should be advised to report any signs of theophylline toxicity including nausea, vomiting, diarrhea, headache, restlessness, insomnia, or irregular heartbeat to their physician.

References

Loi CM, Wei X, Parker BM, Korrapati MR, Vestal RE "The effect of tocainide on theophylline metabolism." Br J Clin Pharmacol 35 (1993): 437-40
Loi C, Wei X, Parker B, Vestal R "Effect of tocainide on theophylline elimination." Clin Pharmacol Ther 51 (1992): 155

Theophylline Liquid

Generic Name: theophylline

Brand name: Elixophyllin, Theo-24, Respbid, T-Phyl, Aerolate III, Slo-Bid Gyrocaps, Slo-Phyllin, Theobid, Theo-Dur, Theolair, Theovent, Bronkodyl, Theo-X, Theo-Time, Theochron, Slo-Phyllin 125, Theoclear LA-130, Aerolate JR, Theolair-SR, Theoclear LA-260, Quibron-T, Quibron-T/SR, Uniphyl, Uni-Dur, Aerolate SR, Slo-Phyllin 80, Theoclear-80, Theo-Dur Sprinkles, Theosol-80, Asmalix, Aquaphyllin, Truxophyllin, Slo-Phyllin 250, TheoCap

Synonyms: Theophylline

What is Theophylline Liquid?

Tocainide

Generic Name: tocainide

Brand name:

Synonyms: Tocainide (Oral)

What is Tocainide?

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In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

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