Thiethylperazine Oral, Intramuscular, Rectal and Trazodone Hydrochloride

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

TraZODone and thiethylperazine may have additive effects in lowering your blood pressure. You may experience headache, dizziness, lightheadedness, fainting, and/or changes in pulse or heart rate. These side effects are most likely to be seen at the beginning of treatment, following a dose increase, or when treatment is restarted after an interruption. Let your doctor know if you develop these symptoms and they do not go away after a few days or they become troublesome. Avoid driving or operating hazardous machinery until you know how the medications affect you, and use caution when getting up from a sitting or lying position. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: The coadministration of phenothiazines with trazodone may produce additive hypotensive effects due to alpha-1 adrenergic blockade. There have been case reports of patients treated with a phenothiazine who developed hypotension following the addition of trazodone therapy. The hypotension resolved with the discontinuation of trazodone. Besides additive effects, it is also possible that competitive inhibition of CYP450 2D6 metabolism may occur, since many phenothiazines as well as antidepressants have been found to be substrates of this isoenzyme. Theoretically, this could produce increased plasma concentrations of phenothiazine and/or trazodone, resulting in increased pharmacologic effects of one or both drugs. In one study, thioridazine (20 mg orally twice a day for one week) increased the plasma concentrations of trazodone and its active metabolite in 11 depressed patients by 36% and 54%, respectively.

MANAGEMENT: Caution is advised if trazodone is administered concomitantly with a phenothiazine. Lower initial dosages and/or more gradual titration are recommended. Patients should be monitored for adverse effects such as hypotension and tachycardia during coadministration, and for altered therapeutic response to the remaining agent following withdrawal of the other agent.

Thiethylperazine Oral, Intramuscular, Rectal

Generic Name: thiethylperazine

Brand name:

Synonyms: Thiethylperazine

What is Thiethylperazine Oral, Intramuscular, Rectal?

Trazodone Hydrochloride

Generic Name: trazodone

Brand name: Desyrel, Desyrel Dividose, Oleptro

Synonyms: Trazodone, TraZODone

What is Trazodone Hydrochloride?