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Tibsovo and Zovia 1/50e

Determining the interaction of Tibsovo and Zovia 1/50e and the possibility of their joint administration.

Check result:
Tibsovo <> Zovia 1/50e
Relevance: 16.09.2022 Reviewer: Shkutko P.M., M.D., in

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Consumer:

Ivosidenib may reduce the blood levels and effects of ethinyl estradiol. If you are using hormonal contraceptives, you may have an increased risk of breakthrough bleeding and unintended pregnancy. You should discuss the use of alternative or additional methods of birth control with your healthcare provider. If you take hormone replacement for menopause, notify your doctor if your medication is no longer controlling your symptoms or you experience abnormal bleeding. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Professional:

ADDITIONAL CONTRACEPTION RECOMMENDED: Coadministration with ivosidenib may decrease the plasma concentrations of contraceptive hormones. The interaction has not been evaluated in pharmacokinetic studies. However, ivosidenib is an inducer of CYP450 3A4 and induces its own metabolism following multiple dosing.

MANAGEMENT: Hormonal contraceptives, including oral, injectable, transdermal, and implantable forms, may not be reliable when used with ivosidenib. Female patients of reproductive potential receiving hormonal contraceptives should consider alternative or additional methods of contraception during treatment with ivosidenib.

References
  • "Product Information. Tibsovo (ivosidenib)." Agios Pharmaceuticals, Cambridge, MA.
Tibsovo

Generic Name: ivosidenib

Brand name: Tibsovo

Synonyms: n.a.

Zovia 1/50e

Generic Name: ethinyl estradiol / ethynodiol

Brand name: Kelnor, Zovia 1/35, Zovia 1/50, Demulen 1/35, Demulen 1/50, Zovia 1/35e, Kelnor 1/50, Kelnor 1/35, Zovia 1/50e

Synonyms: Zovia 1/50, Zovia 1/50E

In the course of checking the drug compatibility and interactions, data from the following reference sources was used: Drugs.com, Rxlist.com, Webmd.com, Medscape.com.

Interaction with food and lifestyle
Disease interaction