Tipiracil and trifluridine and Zidovudine Capsules and Tablets

In the database of official manuals used in the service creation an interaction registered by statistical results of studies was found, which can either lead to negative consequences for the patient health or strengthen a mutual positive effect. A doctor should be consulted to address the issue of joint drug administration.

Trifluridine may decrease the effects of zidovudine. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your symptoms worsen or your condition changes during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

MONITOR: Coadministration with trifluridine may decrease the therapeutic effects of drugs that are substrates of thymidine kinase, such as zidovudine. The proposed mechanism is competitive inhibition for activation (i.e., phosphorylation) via thymidine kinase.

MANAGEMENT: Caution is advised if trifluridine is used concomitantly with drugs that are substrates of thymidine kinase. Patients should be monitored for loss of therapeutic efficacy. If the concomitant drug is an antiviral medication, patients should be monitored for loss of antiviral efficacy and an alternative antiviral agent that is not a thymidine kinase substrate, such as lamivudine, zalcitabine, didanosine and/or abacavir should be considered.

Tipiracil and trifluridine

Generic Name: tipiracil / trifluridine

Brand name: Lonsurf

Synonyms: Trifluridine and Tipiracil

What is Tipiracil and trifluridine?

Zidovudine Capsules and Tablets

Generic Name: zidovudine

Brand name: Retrovir

Synonyms: Zidovudine (oral/injection), Zidovudine

What is Zidovudine Capsules and Tablets?